Pii: S0304-3959(00)00325-0
نویسندگان
چکیده
Processing of nociceptive information can be modulated at various levels in spinal cord that may range from changes of neurotransmitter release from primary afferent Ad or C-®bres to excitability changes of spinal interneurones or motoneurones. The site and mechanism of action of spinal analgesics has been assessed with a number of in vivo and in vitro methods with sometimes con ̄icting results. Here, we have used transverse spinal cord slices with attached dorsal roots to simultaneously record monoand polysynaptic Ad -®bre-evoked ®eld potentials in super®cial spinal dorsal horn. Two classical spinal analgesics, morphine and clonidine, and the metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD) differentially affected monoand polysynaptic Ad -®breevoked transmission in spinal dorsal horn. Polysynaptic responses were dose-dependently inhibited while the monosynaptic response remained unaffected. These results suggest that spinal analgesics may preferentially affect polysynaptic but not monosynaptic Ad-®breevoked responses in super®cial spinal dorsal horn. q 2000 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.
منابع مشابه
Pii: S0010-8545(00)00325-8
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